Alzheimer’s disease (AD) manifests as a progressive cognitive decline affecting the individual’s memory, language, social functioning, etc. It leads to complete dependency for basic activities of daily living and premature death. It’s a condition that affects 44 million people worldwide, 5 million in the United States alone. Although there are several forms of dementia, AD is the most common, comprising 70 to 90% of all cases.1
AD is caused by abnormal brain lesions called plaques. These abnormalities block cell to cell communication and trigger an immune response that leads to premature cell death.2 It remains unclear what exactly leads to deposition of these plaques however. A few risk factors have been identified. These include advanced age3, individuals with two APOE4 genes4, obesity5, diabetes6, insulin resistance, family history of AD7, hypertension8, hormonal imbalances9, smoking10, chronic stress, traumatic brain injuries, etc.
One of our beliefs is the “DNA is not destiny.” We provide actionable advice regarding nutrition which has been shown to improve memory, executive function, global cognition.11 We also aim to decrease chronic inflammation by optimizing gut health12 and administering intravenous ozone therapy. Finally, we also provide input regarding exercise, specific multivitamins, dietary supplements, as well as bioidentical hormone replacement therapy — all meant to turn the tide against genetic predisposition.
- M.A.,. Prince, M. Guerchet: World Alzheimer report 2014. 2014) (Alzheimer’s Disease International (ADI): World Alzheimer Report 2010: The Global Economic Impact Of Dementia. 2010http://www.alz.org/documents/national/world_alzheimer_report_2010.pdf Accessed 5.10.15
- H. Akiyama, S. Barger, S. Barnum, et al.: Inflammation and Alzheimer’s disease.Neurobiol Aging. 21 (3):383-421 2000
- L.E. Hebert, J. Weuve, P.A. Scherr, D.A. Evans: Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology. 80 (19):1778-17832013
- M. Gatz, B. Lowe, S. Berg, et al.: Dementia: not just a search for the gene.Gerontologist. 34 (2):251-255 1994
- G. Razay, A. Vreugdenhil: Obesity in middle age and future risk of dementia: midlife obesity increases risk of future dementia. BMJ. [Comment Letter]. 331 (7514):455 2005
- F. Pasquier, A. Boulogne, D. Leys, P. Fontaine: Diabetes mellitus and dementia.Diabetes Metab. [Review]. 32 (5 Pt 1):403-414 2006
- N.D. Selezneva, I.F. Roshchina, S.I. Gavrilova, et al.: [Mental disorders of cognitive and non-cognitive spectrum in the first-degree relatives of patients with Alzheimer’s disease]. Zh Nevrol Psikhiatr Im S S Korsak. 112 (10):8-13 2012
- G.E. Swan, C. DeCarli, B.L. Miller, et al.: Association of midlife blood pressure to late-life cognitive decline and brain morphology. Neurology. 51 (4):986-993 1998
- E.M. Schrijvers, N. Direk, P.J. Koudstaal, et al.: Associations of serum cortisol with cognitive function and dementia: the Rotterdam Study. Journal of Alzheimer’s Disease.25 (4):671-677 2011
- J.K. Cataldo, J.J. Prochaska, S.A. Glantz: Cigarette smoking is a risk factor for Alzheimer’s Disease: an analysis controlling for tobacco industry affiliation. J Alzheimers Dis. 19 (2):465-480 2010
- C. Valls-Pedret, A. Sala-Vila, M. Serra-Mir, et al.: Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med. 175:1094-1103 2015
- L. Pastorelli, C. De Salvo, J.R. Mercado, et al.: Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front Immunol. [Review]. 4:280 2013