Research has shown that a cornerstone of the aging process is genomic instability and telomere attrition, i.e. damage to DNA that takes place over time.
Cells that accrue such DNA damage lose the ability to function appropriately, regulate themselves, and to communicate with other cells. To counteract these adverse effects, cells contain groups of proteins tasked with repairing DNA damage as it occurs. Examples of such classes of repair proteins include sirtuins and poly-ADP-ribose polymerases (PARPs).
As DNA damage occurs with more frequency during advanced years, sirtuins and PARPs are called on with more regularity to take care of the problem. Generally, there are plenty of sirtuins and PARPs available for the job.
However, both of these classes of proteins require NAD+ as a cofactor and it is the supply of this fuel that declines with aging.
As an aside, beyond DNA-repair, there are many other reactions in the body that also rely on having an adequate supply of NAD+. Its paucity leads to fatigue, malaise, propensity for infections, depression, substance abuse, etc. As a result of the involvement of NAD+ throughout a wide range of functions in the body, clients of all ages and backgrounds have been inquiring about NAD+ therapy.
There are oral supplements available, such as niacin, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN), which are converted to NAD+ in the body.
However, its still questionable if this translates into higher NAD+ levels inside of cells.
Moreover, just about any drug taken orally is partially metabolized and cleared from the body by the liver. When NAD+ is given intravenously, it bypasses such clearance and is readily available for use by the body.
Intravenous NAD+ is not like taking any other supplement, it has to be administered in a medical setting. It’s a potent part of our intravenous cocktail and our clients have been raving about its benefits.
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